Enterococcus faecium PBP5-S/R, the missing link between PBP5-S and PBP5-R.
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ABSTRACT:
SUBMITTER: Pietta E
PROVIDER: S-EPMC4249377 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
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Enterococcus faecium PBP5-S/R, the missing link between PBP5-S and PBP5-R.
Pietta Ester E Montealegre Maria Camila MC Roh Jung Hyeob JH Cocconcelli Pier Sandro PS Murray Barbara E BE
Antimicrobial agents and chemotherapy 20140902 11
During a study to investigate the evolution of ampicillin resistance in Enterococcus faecium, we observed that a number of E. faecium strains, mainly from the recently described subclade A2, showed PBP5 sequences in between PBP5-S and PBP5-R. These hybrid PBP5-S/R patterns reveal a progression of amino acid changes from the S form to the R form of this protein; however, these changes do not strictly correlate with changes in ampicillin MICs. ...[more]
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