Unknown

Dataset Information

0

In Vitro selection of Neisseria gonorrhoeae mutants with elevated MIC values and increased resistance to cephalosporins.

ABSTRACT: Strains of Neisseria gonorrhoeae with mosaic penA genes bearing novel point mutations in penA have been isolated from ceftriaxone treatment failures. Such isolates exhibit significantly higher MIC values to third-generation cephalosporins. Here we report the in vitro isolation of two mutants with elevated MICs to cephalosporins. The first possesses a point mutation in the transpeptidase region of the mosaic penA gene, and the second contains an insertion mutation in pilQ.

SUBMITTER: Johnson SR 

PROVIDER: S-EPMC4249396 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

In Vitro selection of Neisseria gonorrhoeae mutants with elevated MIC values and increased resistance to cephalosporins.

Johnson Steven R SR   Grad Yonatan Y   Ganakammal Satishkumar Ranganathan SR   Burroughs Mark M   Frace Mike M   Lipsitch Marc M   Weil Ryan R   Trees David D  

Antimicrobial agents and chemotherapy 20140908 11

Strains of Neisseria gonorrhoeae with mosaic penA genes bearing novel point mutations in penA have been isolated from ceftriaxone treatment failures. Such isolates exhibit significantly higher MIC values to third-generation cephalosporins. Here we report the in vitro isolation of two mutants with elevated MICs to cephalosporins. The first possesses a point mutation in the transpeptidase region of the mosaic penA gene, and the second contains an insertion mutation in pilQ. ...[more]

Similar Datasets

Unknown Shanghai Neisseria gonorrhoeae Isolates Exhibit Resistance to Extended-Spectrum Cephalosporins and Clonal Distribution.
| S-EPMC7573285 | biostudies-literature
Unknown Neisseria gonorrhoeae and extended-spectrum cephalosporins in California: surveillance and molecular detection of mosaic penA.
| S-EPMC4235022 | biostudies-literature
Unknown Neisseria cinerea with High Ceftriaxone MIC Is a Source of Ceftriaxone and Cefixime Resistance-Mediating penA Sequences in Neisseria gonorrhoeae.
| S-EPMC5826163 | biostudies-literature
Unknown In Vitro Activity of Delafloxacin against Clinical Neisseria gonorrhoeae Isolates and Selection of Gonococcal Delafloxacin Resistance.
| S-EPMC4862482 | biostudies-literature
Unknown Molecular Assay for Detection of Genetic Markers Associated with Decreased Susceptibility to Cephalosporins in Neisseria gonorrhoeae.
| S-EPMC4473228 | biostudies-literature
Unknown Sudden emergence of a <i>Neisseria gonorrhoeae</i> clade with reduced susceptibility to extended-spectrum cephalosporins, Norway.
| S-EPMC8116678 | biostudies-literature
Unknown In Vitro Activity of Gepotidacin (GSK2140944) against Neisseria gonorrhoeae.
| S-EPMC5328517 | biostudies-other
Transcriptomics Transcriptomics of Neisseria gonorrhoeae
2016-05-24 | GSE73032 | GEO
Unknown Characterization of Neisseria gonorrhoeae isolates detected in Switzerland (1998-2012): emergence of multidrug-resistant clones less susceptible to cephalosporins.
| S-EPMC3941690 | biostudies-literature
Unknown Gradient diffusion susceptibility testing for <i>Neisseria gonorrhoeae</i>: an accurate alternative to agar dilution in high-MIC strains?
| S-EPMC7494190 | biostudies-literature