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The role of tyrosine kinases in systemic lupus erythematosus and their potential as therapeutic targets.

ABSTRACT: The autoimmune disease systemic lupus erythematosus is characterized by loss of tolerance to nuclear antigens. Breakdown of tolerance is associated with alterations in T-cell and B-cell receptor signal transduction, including increased protein phosphorylation that may underlie pathogenesis and explain the characteristic hyperactivity of T and B cells and other immune cells in active disease. Tyrosine kinases play a central role in signaling processes in cells known to be important in the pathogenesis of autoimmune diseases. Considerable progress has been made in understanding the function of tyrosine kinases in immune cell signaling pathways. In this review, we will summarize the function of tyrosine kinases and their novel inhibitors from studies made in animal lupus models and systemic lupus erythematosus patients.

SUBMITTER: Shao WH

PROVIDER: S-EPMC4249585 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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The role of tyrosine kinases in systemic lupus erythematosus and their potential as therapeutic targets.

Shao Wen-Hai WH Cohen Philip L PL

Expert review of clinical immunology 20140329 5

The autoimmune disease systemic lupus erythematosus is characterized by loss of tolerance to nuclear antigens. Breakdown of tolerance is associated with alterations in T-cell and B-cell receptor signal transduction, including increased protein phosphorylation that may underlie pathogenesis and explain the characteristic hyperactivity of T and B cells and other immune cells in active disease. Tyrosine kinases play a central role in signaling processes in cells known to be important in the pathoge ...[more]

PMID: 24678775

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