Ontology highlight
ABSTRACT:
SUBMITTER: Mittal S
PROVIDER: S-EPMC4250181 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Mittal Shruti S Singh Laishram Rajendrakumar LR
PloS one 20141201 12
Macromolecular crowding has been shown to have an exacerbating effect on the aggregation propensity of amyloidogenic proteins; while having an inhibitory effect on the non-amyloidogenic proteins. However, the results concerning aggregation propensity of non-amyloidogenic proteins have not been convincing due to the contrasting effect on holo-LA, which despite being a non-amyloidogenic protein was observed to aggregate under crowded conditions. In the present study, we have extensively characteri ...[more]