Dataset Information

Recovery from anemia in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation--prevalence, predictors and clinical outcome.

ABSTRACT:

Introduction

Preoperative anemia is common in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI) and has been linked to a poorer outcome--including a higher 1-year mortality. The aim of this study was to investigate the impact of successful TAVI on baseline anemia.

Methods

A total of 253 patients who survived at least 1 year following TAVI were included in this study. The prevalence, predictors and clinical outcome of hemoglobin (Hb)-recovery were assessed.

Results

The prevalence of baseline anemia was 49% (n?=?124)--recovery from anemia occurred in 40% of the anemic patients (n?=?49) at 1 year after TAVI with an increase in mean Hb-level of 1.35 g/dL from baseline. This increase was not related to an improvement in renal function. At multivariate analysis, a high peak gradient (OR 4.82, P?=?0.003) was shown to be an independent predictor for Hb-recovery, while blood transfusion (OR 0.31, P?=?0.038) and chronic kidney disease (CKD, OR 0.33, P?=?0.043) were identified as negative predictors at, respectively, one and two years after TAVI. When compared to patients without baseline anemia, those anemic patients with Hb-recovery had a similar functional improvement (OR 0.98, P?=?0.975), whereas those without Hb-recovery had a significantly lower likelihood of functional improvement with ?2 NYHA classes (OR 0.49, P?=?0.034) and a higher likelihood of re-hospitalization within the first year after TAVI (OR 1.91, P?=?0.024).

Conclusion

Recovery from anemia occurs in 40% of anemic patients at 1 year after TAVI--mainly in those with a high gradient and without CKD. Blood transfusion was found to have a transient adverse effect on this Hb-recovery. Finally, anemic patients without Hb-recovery experience less functional improvement and have a higher re-hospitalization rate within the first year after TAVI.

SUBMITTER: De Backer O

PROVIDER: S-EPMC4250195 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

Recovery from anemia in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation--prevalence, predictors and clinical outcome.

De Backer Ole O Arnous Samer S Lønborg Jacob J Brooks Matthew M Biasco Luigi L Jönsson Anders A Franzen Olaf W OW Søndergaard Lars L

PloS one 20141201 12

<h4>Introduction</h4>Preoperative anemia is common in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI) and has been linked to a poorer outcome--including a higher 1-year mortality. The aim of this study was to investigate the impact of successful TAVI on baseline anemia.<h4>Methods</h4>A total of 253 patients who survived at least 1 year following TAVI were included in this study. The prevalence, predictors and clinical outcome of hemoglobin (Hb)-rec ...[more]

PMID: 25437191

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Dataset Information

Recovery from anemia in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation--prevalence, predictors and clinical outcome.

Introduction

Methods

Results

Conclusion

Publications

Recovery from anemia in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation--prevalence, predictors and clinical outcome.

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