Ontology highlight
ABSTRACT:
SUBMITTER: Marchesi S
PROVIDER: S-EPMC4250264 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Developmental cell 20141124 4
Cells entering mitosis become rounded, lose attachment to the substrate, and increase their cortical rigidity. Pivotal to these events is the dismantling of focal adhesions (FAs). How mitotic reshaping is linked to commitment to divide is unclear. Here, we show that DEPDC1B, a protein that accumulates in G2, coordinates de-adhesion events and cell-cycle progression at mitosis. DEPDC1B functions as an inhibitor of a RhoA-based signaling complex, which assembles on the FA-associated protein tyrosi ...[more]