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Mapping the accumulation of co-infiltrating CNS dendritic cells and encephalitogenic T cells during EAE.

ABSTRACT: Evidence from experimental autoimmune encephalomyelitis (EAE) suggests that CNS-infiltrating dendritic cells (DCs) are crucial for restimulation of coinfiltrating T cells. Here we systematically quantified and visualized the distribution and interaction of CNS DCs and T cells during EAE. We report marked periventricular accumulation of DCs and myelin-specific T cells during EAE disease onset prior to accumulation in the spinal cord, indicating that the choroid plexus-CSF axis is a CNS entry portal. Moreover, despite emphasis on spinal cord inflammation in EAE and in correspondence with MS pathology, inflammatory lesions containing interacting DCs and T cells are present in specific brain regions.

SUBMITTER: Clarkson BD

PROVIDER: S-EPMC4250311 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Mapping the accumulation of co-infiltrating CNS dendritic cells and encephalitogenic T cells during EAE.

Clarkson Benjamin D BD Walker Alec A Harris Melissa M Rayasam Aditya A Sandor Matyas M Fabry Zsuzsanna Z

Journal of neuroimmunology 20140928 1-2

Evidence from experimental autoimmune encephalomyelitis (EAE) suggests that CNS-infiltrating dendritic cells (DCs) are crucial for restimulation of coinfiltrating T cells. Here we systematically quantified and visualized the distribution and interaction of CNS DCs and T cells during EAE. We report marked periventricular accumulation of DCs and myelin-specific T cells during EAE disease onset prior to accumulation in the spinal cord, indicating that the choroid plexus-CSF axis is a CNS entry port ...[more]

PMID: 25288303

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