Unknown

Dataset Information

0

Mapping the accumulation of co-infiltrating CNS dendritic cells and encephalitogenic T cells during EAE.


ABSTRACT: Evidence from experimental autoimmune encephalomyelitis (EAE) suggests that CNS-infiltrating dendritic cells (DCs) are crucial for restimulation of coinfiltrating T cells. Here we systematically quantified and visualized the distribution and interaction of CNS DCs and T cells during EAE. We report marked periventricular accumulation of DCs and myelin-specific T cells during EAE disease onset prior to accumulation in the spinal cord, indicating that the choroid plexus-CSF axis is a CNS entry portal. Moreover, despite emphasis on spinal cord inflammation in EAE and in correspondence with MS pathology, inflammatory lesions containing interacting DCs and T cells are present in specific brain regions.

SUBMITTER: Clarkson BD 

PROVIDER: S-EPMC4250311 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Mapping the accumulation of co-infiltrating CNS dendritic cells and encephalitogenic T cells during EAE.

Clarkson Benjamin D BD   Walker Alec A   Harris Melissa M   Rayasam Aditya A   Sandor Matyas M   Fabry Zsuzsanna Z  

Journal of neuroimmunology 20140928 1-2


Evidence from experimental autoimmune encephalomyelitis (EAE) suggests that CNS-infiltrating dendritic cells (DCs) are crucial for restimulation of coinfiltrating T cells. Here we systematically quantified and visualized the distribution and interaction of CNS DCs and T cells during EAE. We report marked periventricular accumulation of DCs and myelin-specific T cells during EAE disease onset prior to accumulation in the spinal cord, indicating that the choroid plexus-CSF axis is a CNS entry port  ...[more]

Similar Datasets

| S-EPMC2942091 | biostudies-literature
2015-08-25 | E-GEOD-72301 | biostudies-arrayexpress
| S-EPMC3903229 | biostudies-literature
| S-EPMC7998427 | biostudies-literature
| S-EPMC4382434 | biostudies-literature
2015-08-25 | GSE72301 | GEO
| S-EPMC10981618 | biostudies-literature
| S-EPMC3906668 | biostudies-literature
| S-EPMC2571937 | biostudies-literature
| S-EPMC3237120 | biostudies-literature