Ontology highlight
ABSTRACT:
SUBMITTER: Hopp SC
PROVIDER: S-EPMC4250380 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Hopp S C SC D'Angelo H M HM Royer S E SE Kaercher R M RM Adzovic L L Wenk G L GL
Neuroscience 20140916
Age-associated memory impairments may result as a consequence of neuroinflammatory induction of intracellular calcium (Ca(+2)) dysregulation. Altered L-type voltage-dependent calcium channel (L-VDCC) and ryanodine receptor (RyR) activity may underlie age-associated learning and memory impairments. Various neuroinflammatory markers are associated with increased activity of both L-VDCCs and RyRs, and increased neuroinflammation is associated with normal aging. In vitro, pharmacological blockade of ...[more]