Ontology highlight
ABSTRACT:
SUBMITTER: Sookoian S
PROVIDER: S-EPMC4250625 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Sookoian Silvia S Castaño Gustavo G Gemma Carolina C Gianotti Tomas-Fernández TF Pirola Carlos-Jose CJ
World journal of gastroenterology 20070801 31
<h4>Aim</h4>To investigate the role of gene variants and derived haplotypes of the CLOCK transcription factor in nonalcoholic fatty liver disease (NAFLD) and their relation with the disease severity.<h4>Methods</h4>A total of 136 patients with NAFLD and 64 healthy individuals were studied. Liver biopsy was performed in 91 patients. Six tag SNPs showing a minor allele frequency > 10% (rs1554483 C/G; rs11932595 A/G; rs4580704 C/G; rs6843722 A/C; rs6850524 C/G and rs4864548 A/G) encompassing 117 kb ...[more]