Ontology highlight
ABSTRACT:
SUBMITTER: Jiang Y
PROVIDER: S-EPMC4250841 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Jiang Yuwei Y Berry Daniel C DC Tang Wei W Graff Jonathan M JM
Cell reports 20141023 3
Adipose tissues have striking plasticity, highlighted by childhood and adult obesity. Using adipose lineage analyses, smooth muscle actin (SMA)-mural cell-fate mapping, and conditional PPARγ deletion to block adipocyte differentiation, we find two phases of adipocyte generation that emanate from two independent adipose progenitor compartments: developmental and adult. These two compartments are sequentially required for organ formation and maintenance. Although both developmental and adult proge ...[more]