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Gold catalyzed cyclization of alkyne-tethered dihydropyrimidones.

ABSTRACT: Dihydropyrimidones are an important class of biologically active heterocycles accessible from the multicomponent Biginelli condensation. Further manipulation of the dihydropyrimidone skeleton gives access to unique heterocycles. Presented herein is a Au-catalyzed cyclization of alkyne-tethered dihydropyrimidones to yield pyridopyrimidones.

SUBMITTER: Brown LE 

PROVIDER: S-EPMC4251731 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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Gold catalyzed cyclization of alkyne-tethered dihydropyrimidones.

Brown Lauren E LE   Dai Peng P   Porco John A JA   Schaus Scott E SE  

Organic letters 20110713 16

Dihydropyrimidones are an important class of biologically active heterocycles accessible from the multicomponent Biginelli condensation. Further manipulation of the dihydropyrimidone skeleton gives access to unique heterocycles. Presented herein is a Au-catalyzed cyclization of alkyne-tethered dihydropyrimidones to yield pyridopyrimidones. ...[more]

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