Ontology highlight
ABSTRACT:
SUBMITTER: Ackermann S
PROVIDER: S-EPMC4251948 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Ackermann Sandra S Kocak Hayriye H Hero Barbara B Ehemann Volker V Kahlert Yvonne Y Oberthuer André A Roels Frederik F Theißen Jessica J Odenthal Margarete M Berthold Frank F Fischer Matthias M
BMC cancer 20141118
<h4>Background</h4>Segmental genomic copy number alterations, such as loss of 11q or 3p and gain of 17q, are well established markers of poor outcome in neuroblastoma, and have been suggested to comprise tumor suppressor genes or oncogenes, respectively. The gene forkhead box P1 (FOXP1) maps to chromosome 3p14.1, a tumor suppressor locus deleted in many human cancers including neuroblastoma. FoxP1 belongs to a family of winged-helix transcription factors that are involved in processes of cellula ...[more]