Ontology highlight
ABSTRACT:
SUBMITTER: Frischmeyer-Guerrerio PA
PROVIDER: S-EPMC4252363 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Frischmeyer-Guerrerio Pamela A PA Keet Corinne A CA Guerrerio Anthony L AL Guerrerio Anthony L AL Chichester Kristin L KL Bieneman Anja P AP Hamilton Robert G RG Wood Robert A RA Schroeder John T JT
Clinical immunology (Orlando, Fla.) 20140827 1
Sublingual (SLIT) and oral immunotherapy (OIT) are promising treatments for food allergy, but underlying mechanisms are poorly understood. Dendritic cells (DCs) induce and maintain Th2-type allergen-specific T cells, and also regulate innate immunity through their expression of Toll-like receptors (TLRs). We examined how SLIT and OIT influenced DC innate and adaptive immune responses in children with IgE-mediated cow's milk (CM) allergy. SLIT, but not OIT, decreased TLR-induced IL-6 secretion by ...[more]