Ontology highlight
ABSTRACT:
SUBMITTER: Wei HJ
PROVIDER: S-EPMC4253450 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Wei Hong-Jian HJ Nickoloff Jac A JA Chen Wei-Hong WH Liu Hen-Yu HY Lo Wen-Cheng WC Chang Ya-Ting YT Yang Pan-Chyr PC Wu Cheng-Wen CW Williams David F DF Gelovani Juri G JG Deng Win-Ping WP
Oncotarget 20141001 19
Several reports suggest that malignant cells generate phenotypic diversity through fusion with various types of stromal cells within the tumor microenvironment. Mesenchymal stem cell (MSC) is one of the critical components in the tumor microenvironment and a promising fusogenic candidate, but the underlying functions of MSC fusion with malignant cell have not been fully examined. Here, we demonstrate that MSCs fuse spontaneously with lung cancer cells, and the latter is reprogrammed to slow grow ...[more]