Drowning stars: reassessing the role of astrocytes in brain edema.
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ABSTRACT:
SUBMITTER: Thrane AS
PROVIDER: S-EPMC4253572 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
Drowning stars: reassessing the role of astrocytes in brain edema.
Thrane Alexander S AS Rangroo Thrane Vinita V Nedergaard Maiken M
Trends in neurosciences 20140915 11
Edema formation frequently complicates brain infarction, tumors, and trauma. Despite the significant mortality of this condition, current treatment options are often ineffective or incompletely understood. Recent studies have revealed the existence of a brain-wide paravascular pathway for cerebrospinal (CSF) and interstitial fluid (ISF) exchange. The current review critically examines the contribution of this 'glymphatic' system to the main types of brain edema. We propose that in cytotoxic edem ...[more]
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