TonEBP/NFAT5 regulates ACTBL2 expression in biomechanically activated vascular smooth muscle cells.

ABSTRACT: Cytoskeletal reorganization and migration are critical responses which enable vascular smooth muscle cells (VSMCs) cells to evade, compensate, or adapt to alterations in biomechanical stress. An increase in wall stress or biomechanical stretch as it is elicited by arterial hypertension promotes their reorganization in the vessel wall which may lead to arterial stiffening and contractile dysfunction. This adaptive remodeling process is dependent on and driven by subtle phenotype changes including those controlling the cytoskeletal architecture and motility of VSMCs. Recently, it has been reported that the transcription factor nuclear factor of activated T-cells 5 (TonEBP/NFAT5) controls critical aspects of the VSMC phenotype and is activated by biomechanical stretch. We therefore hypothesiz

SUBMITTER: Hodebeck M 

PROVIDER: S-EPMC4253659 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature