Redox regulation of botulinum neurotoxin toxicity: therapeutic implications.
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ABSTRACT:
SUBMITTER: Montal M
PROVIDER: S-EPMC4253726 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
Redox regulation of botulinum neurotoxin toxicity: therapeutic implications.
Trends in molecular medicine 20140918 11
Botulinum neurotoxin causes botulism, and the only effective antidote is the antitoxin. Botulinum neurotoxins are disulfide linked di-chain proteins encompassing a light chain Zn2+-protease that is translocated by a heavy chain channel from the synaptic vesicle lumen into the neuronal cytosol where it acts. Protease release from the channel is required for toxicity. The Thioredoxin Reductase-Thioredoxin system cleaves the interchain disulfide, and its inhibition prevents neurotoxicity, and may p ...[more]
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