Ontology highlight
ABSTRACT:
SUBMITTER: Farnoud AM
PROVIDER: S-EPMC4254033 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Farnoud Amir M AM Mor Visesato V Singh Ashutosh A Del Poeta Maurizio M
FEBS letters 20140918 21
Cryptococcus neoformans is a facultative intracellular pathogen, which can replicate in the acidic environment inside phagolysosomes. Deletion of the enzyme inositol-phosphosphingolipid-phospholipase-C (Isc1) makes C. neoformans hypersensitive to acidic pH likely by inhibiting the function of the proton pump, plasma membrane ATPase (Pma1). In this work, we examined the role of Isc1 on Pma1 transport and oligomerization. Our studies showed that Isc1 deletion did not affect Pma1 synthesis or trans ...[more]