Ontology highlight
ABSTRACT:
SUBMITTER: Hariri H
PROVIDER: S-EPMC4254083 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Hariri Hanaa H Bhattacharya Nilakshee N Johnson Kerri K Noble Alex J AJ Stagg Scott M SM
Journal of molecular biology 20140902 22
The small GTPase protein Sar1 is known to be involved in both the initiation of COPII-coated vesicle formation and scission of the nascent vesicle from the endoplasmic reticulum. The molecular details for the mechanism of membrane remodeling by Sar1 remain unresolved. Here, we show that Sar1 transforms synthetic liposomes into structures of different morphologies including tubules and detached vesicles. We demonstrate that Sar1 alone is competent for vesicle scission in a manner that depends on ...[more]