Outer retinal tubulation in the comparison of age-related macular degeneration treatments trials (CATT).

ABSTRACT:

Purpose

To determine the prevalence of, risk factors for, and visual acuity (VA) correlations with outer retinal tubulation (ORT) seen on spectral-domain optical coherence tomography (SD OCT) in eyes with neovascular age-related macular degeneration (AMD) after anti-vascular endothelial growth factor (VEGF) therapy.

Design

Prospective cohort study within a randomized clinical trial.

Participants

Patients with SD OCT images at weeks 56 and 104 in the Comparison of AMD Treatments Trials (CATT).

Methods

Participants in the CATT were assigned randomly to ranibizumab (0.5 mg) or bevacizumab (1.25 mg) treatment and to a monthly or pro re nata (PRN) injection-dosing regimen. A subset of eyes was imaged with SD OCT beginning at week 56. Cirrus 512×128 or Spectralis 20°

SUBMITTER: Lee JY 

PROVIDER: S-EPMC4254295 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature