Ontology highlight
ABSTRACT:
SUBMITTER: Shin AC
PROVIDER: S-EPMC4254305 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Shin Andrew C AC Fasshauer Martin M Filatova Nika N Grundell Linus A LA Zielinski Elizabeth E Zhou Jian-Ying JY Scherer Thomas T Lindtner Claudia C White Phillip J PJ Lapworth Amanda L AL Ilkayeva Olga O Knippschild Uwe U Wolf Anna M AM Scheja Ludger L Grove Kevin L KL Smith Richard D RD Qian Wei-Jun WJ Lynch Christopher J CJ Newgard Christopher B CB Buettner Christoph C
Cell metabolism 20141009 5
Circulating branched-chain amino acid (BCAA) levels are elevated in obesity/diabetes and are a sensitive predictor for type 2 diabetes. Here we show in rats that insulin dose-dependently lowers plasma BCAA levels through induction of hepatic protein expression and activity of branched-chain α-keto acid dehydrogenase (BCKDH), the rate-limiting enzyme in the BCAA degradation pathway. Selective induction of hypothalamic insulin signaling in rats and genetic modulation of brain insulin receptors in ...[more]