Genetic background determines if Stat5b suppresses or enhances murine hepatocarcinogenesis.
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ABSTRACT:
SUBMITTER: Oberley CC
PROVIDER: S-EPMC4254363 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Genetic background determines if Stat5b suppresses or enhances murine hepatocarcinogenesis.
Oberley Christopher C CC Bilger Andrea A Drinkwater Norman R NR
Molecular carcinogenesis 20140517 10
Murine hepatocarcinogenesis requires growth hormone (GH). To determine if the GH-responsive transcription factor STAT5b (signal transducer and activator of transcription 5b) is also required, we compared the hepatic gene expression profiles of global Stat5b null mice to cancer-resistant mice mutant in the GH pathway-GH-deficient little and androgen receptor-null Tfm males. We found a high degree of overlap among Tfm, little, and Stat5b null males. The liver cancer susceptibility of global Stat5b ...[more]
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