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Molecular mechanisms for contribution of MHC molecules to autoimmune diseases.

ABSTRACT: It will soon be 50 years since the first MHC associations with human disease were described. These seminal studies opened a flourishing area of research, yet much remains to be discovered. Genome-wide association studies of autoimmune diseases have demonstrated that the MHC region has effect sizes that supersede those for any non-MHC locus for most diseases. Thus, an understanding of how particular MHC alleles confer susceptibility will be essential for a comprehensive understanding of autoimmune disease pathogenesis. Here we review recent exciting findings in this important field.

SUBMITTER: Sollid LM

PROVIDER: S-EPMC4254370 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Molecular mechanisms for contribution of MHC molecules to autoimmune diseases.

Sollid Ludvig M LM Pos Wouter W Wucherpfennig Kai W KW

Current opinion in immunology 20140915

It will soon be 50 years since the first MHC associations with human disease were described. These seminal studies opened a flourishing area of research, yet much remains to be discovered. Genome-wide association studies of autoimmune diseases have demonstrated that the MHC region has effect sizes that supersede those for any non-MHC locus for most diseases. Thus, an understanding of how particular MHC alleles confer susceptibility will be essential for a comprehensive understanding of autoimmun ...[more]

PMID: 25216261

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