Ontology highlight
ABSTRACT:
SUBMITTER: Mattison JA
PROVIDER: S-EPMC4254394 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Mattison Julie A JA Wang Mingyi M Bernier Michel M Zhang Jing J Park Sung-Soo SS Maudsley Stuart S An Steven S SS Santhanam Lakshmi L Martin Bronwen B Faulkner Shakeela S Morrell Christopher C Baur Joseph A JA Peshkin Leonid L Sosnowska Danuta D Csiszar Anna A Herbert Richard L RL Tilmont Edward M EM Ungvari Zoltan Z Pearson Kevin J KJ Lakatta Edward G EG de Cabo Rafael R de Cabo Rafael R
Cell metabolism 20140529 1
Central arterial wall stiffening, driven by a chronic inflammatory milieu, accompanies arterial diseases, the leading cause of cardiovascular (CV) morbidity and mortality in Western society. An increase in central arterial wall stiffening, measured as an increase in aortic pulse wave velocity (PWV), is a major risk factor for clinical CV disease events. However, no specific therapies to reduce PWV are presently available. In rhesus monkeys, a 2 year diet high in fat and sucrose (HFS) increases n ...[more]