Ontology highlight
ABSTRACT:
SUBMITTER: Gorczyca DA
PROVIDER: S-EPMC4254518 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Gorczyca David A DA Younger Susan S Meltzer Shan S Kim Sung Eun SE Cheng Li L Song Wei W Lee Hye Young HY Jan Lily Yeh LY Jan Yuh Nung YN
Cell reports 20141106 4
A major gap in our understanding of sensation is how a single sensory neuron can differentially respond to a multitude of different stimuli (polymodality), such as propio- or nocisensation. The prevailing hypothesis is that different stimuli are transduced through ion channels with diverse properties and subunit composition. In a screen for ion channel genes expressed in polymodal nociceptive neurons, we identified Ppk26, a member of the trimeric degenerin/epithelial sodium channel (DEG/ENaC) fa ...[more]