GD2-targeted immunotherapy and radioimmunotherapy.
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ABSTRACT:
SUBMITTER: Dobrenkov K
PROVIDER: S-EPMC4254523 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
GD2-targeted immunotherapy and radioimmunotherapy.
Dobrenkov Konstantin K Cheung Nai-Kong V NK
Seminars in oncology 20140721 5
Ganglioside GD2 is a tumor-associated surface antigen found in a broad spectrum of human cancers and stem cells. They include pediatric embryonal tumors (neuroblastoma, retinoblastoma, brain tumors, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma), as well as adult cancers (small cell lung cancer, melanoma, soft tissue sarcomas). Because of its restricted normal tissue distribution, GD2 has been proven safe for antibody targeting. Anti-GD2 antibody is now incorporated into the standard of care for ...[more]
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