Tritium-labeled (E,E)-2,5-bis(4'-hydroxy-3'-carboxystyryl)benzene as a probe for ?-amyloid fibrils.

ABSTRACT: Accumulation of A? in the brains of Alzheimer disease (AD) patients reflects an imbalance between A? production and clearance from their brains. Alternative cleavage of amyloid precursor protein (APP) by processing proteases generates soluble APP fragments including the neurotoxic amyloid A?40 and A?42 peptides that assemble into fibrils and form plaques. Plaque-buildup occurs over an extended time-frame, and the early detection and modulation of plaque formation are areas of active research. Radiolabeled probes for the detection of amyloid plaques and fibrils in living subjects are important for noninvasive evaluation of AD diagnosis, progression, and differentiation of AD from other neurodegenerative diseases and age-related cognitive decline. Tritium-labeled (E,E)-1-[(3)H]-2,5-bis(4'-hydroxy-3'-carbomethoxystyryl)benzene possesses an improved level of chemical stability relative to a previously reported radioiodinated analog for radiometric quantification of A? plaque and tau pathology in brain tissue and in vitro studies with synthetic A? and tau fibrils.

SUBMITTER: Matveev SV 

PROVIDER: S-EPMC4254541 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature