Ontology highlight
ABSTRACT:
SUBMITTER: Ruffell B
PROVIDER: S-EPMC4254570 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Ruffell Brian B Chang-Strachan Debbie D Chan Vivien V Rosenbusch Alexander A Ho Christine M T CM Pryer Nancy N Daniel Dylan D Hwang E Shelley ES Rugo Hope S HS Coussens Lisa M LM
Cancer cell 20141016 5
Blockade of colony-stimulating factor-1 (CSF-1) limits macrophage infiltration and improves response of mammary carcinomas to chemotherapy. Herein we identify interleukin (IL)-10 expression by macrophages as the critical mediator of this phenotype. Infiltrating macrophages were the primary source of IL-10 within tumors, and therapeutic blockade of IL-10 receptor (IL-10R) was equivalent to CSF-1 neutralization in enhancing primary tumor response to paclitaxel and carboplatin. Improved response to ...[more]