Ontology highlight
ABSTRACT:
SUBMITTER: Chen JJ
PROVIDER: S-EPMC4254654 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Chen John J JJ Genereux Joseph C JC Qu Song S Hulleman John D JD Shoulders Matthew D MD Wiseman R Luke RL
Chemistry & biology 20141023 11
Systemic amyloidoses result from the aberrant secretion of destabilized, amyloidogenic proteins to the serum where they aggregate into proteotoxic soluble aggregates and amyloid fibrils. Few therapeutic approaches exist to attenuate extracellular pathologic aggregation of amyloidogenic proteins, necessitating the development of new strategies to intervene in these devastating disorders. We show that stress-independent activation of the Unfolded Protein Response-associated transcription factor AT ...[more]