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MicroRNA expression profiling in PBMCs: a potential diagnostic biomarker of chronic hepatitis C.

ABSTRACT: The expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 in PBMCs were significantly higher in CHC patients compared with healthy controls and significantly different between CHC patients with HCV genotype 1 (GT-1) and non-genotype-1 (non-GT-1). Multivariate logistic regression analysis also showed that patients with high expression levels of the six target miRNAs had an approximately 7.202-fold risk of CHC compared with those with low expression levels of the target miRNAs. We concluded that the expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 target miRNAs in PBMCs of CHC may act as significant risk biomarkers for the development of CHC.

SUBMITTER: Chang CC

PROVIDER: S-EPMC4255053 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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MicroRNA expression profiling in PBMCs: a potential diagnostic biomarker of chronic hepatitis C.

Chang Chiu-Chun CC Lin Chun-Che CC Hsieh Wan-Ling WL Lai Hsin-Wu HW Tsai Chia-Hsun CH Cheng Ya-Wen YW

Disease markers 20141118

The expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 in PBMCs were significantly higher in CHC patients compared with healthy controls and significantly different between CHC patients with HCV genotype 1 (GT-1) and non-genotype-1 (non-GT-1). Multivariate logistic regression analysis also showed that patients with high expression levels of the six target miRNAs had an approximately 7.202-fold risk of CHC compared with those with low expression levels of the target miRNAs. We ...[more]

PMID: 25505813

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