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Multiple types of logic gates based on a single G-quadruplex DNA strand.

ABSTRACT: In this work, we demonstrate the use of a single DNA strand and G-quadruplex-specific dye NMM as a label-free switch for the construction of series of basic logic gates (YES, NOT, OR, INHIBIT, NOR, AND). The simple GT-rich sequence could be used to interact with several molecules (K(+), thrombin, Hg(2+), and Pb(2+)) to form different structures that can be distinguished by the label-free dye NMM. Our study showed that a single G-qudruplex DNA strand can function as multiple types of one-input and two-input logic gates with different combinations of input molecules.

SUBMITTER: Guo Y

PROVIDER: S-EPMC4255190 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Multiple types of logic gates based on a single G-quadruplex DNA strand.

Guo Yahui Y Zhou Lu L Xu Lijun L Zhou Xiaodong X Hu Jiming J Pei Renjun R

Scientific reports 20141204

In this work, we demonstrate the use of a single DNA strand and G-quadruplex-specific dye NMM as a label-free switch for the construction of series of basic logic gates (YES, NOT, OR, INHIBIT, NOR, AND). The simple GT-rich sequence could be used to interact with several molecules (K(+), thrombin, Hg(2+), and Pb(2+)) to form different structures that can be distinguished by the label-free dye NMM. Our study showed that a single G-qudruplex DNA strand can function as multiple types of one-input an ...[more]

PMID: 25472865

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