Ontology highlight
ABSTRACT:
SUBMITTER: Brehme M
PROVIDER: S-EPMC4255334 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Brehme Marc M Voisine Cindy C Rolland Thomas T Wachi Shinichiro S Soper James H JH Zhu Yitan Y Orton Kai K Villella Adriana A Garza Dan D Vidal Marc M Ge Hui H Morimoto Richard I RI
Cell reports 20141023 3
Chaperones are central to the proteostasis network (PN) and safeguard the proteome from misfolding, aggregation, and proteotoxicity. We categorized the human chaperome of 332 genes into network communities using function, localization, interactome, and expression data sets. During human brain aging, expression of 32% of the chaperome, corresponding to ATP-dependent chaperone machines, is repressed, whereas 19.5%, corresponding to ATP-independent chaperones and co-chaperones, are induced. These r ...[more]