NQO2 is a reactive oxygen species generating off-target for acetaminophen.
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ABSTRACT:
SUBMITTER: Miettinen TP
PROVIDER: S-EPMC4255684 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
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NQO2 is a reactive oxygen species generating off-target for acetaminophen.
Miettinen Teemu P TP Björklund Mikael M
Molecular pharmaceutics 20141024 12
The analgesic and antipyretic compound acetaminophen (paracetamol) is one of the most used drugs worldwide. Acetaminophen overdose is also the most common cause for acute liver toxicity. Here we show that acetaminophen and many structurally related compounds bind quinone reductase 2 (NQO2) in vitro and in live cells, establishing NQO2 as a novel off-target. NQO2 modulates the levels of acetaminophen derived reactive oxygen species, more specifically superoxide anions, in cultured cells. In human ...[more]
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