Ontology highlight
ABSTRACT:
SUBMITTER: Cerny D
PROVIDER: S-EPMC4256468 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Cerny Daniela D Haniffa Muzlifah M Shin Amanda A Bigliardi Paul P Tan Bien Keem BK Lee Bernett B Poidinger Michael M Tan Ern Yu EY Ginhoux Florent F Fink Katja K
PLoS pathogens 20141204 12
Dengue is a growing global concern with 390 million people infected each year. Dengue virus (DENV) is transmitted by mosquitoes, thus host cells in the skin are the first point of contact with the virus. Human skin contains several populations of antigen-presenting cells which could drive the immune response to DENV in vivo: epidermal Langerhans cells (LCs), three populations of dermal dendritic cells (DCs), and macrophages. Using samples of normal human skin we detected productive infection of ...[more]