Ontology highlight
ABSTRACT:
SUBMITTER: Helm D
PROVIDER: S-EPMC4256517 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Helm Dominic D Vissers Johannes P C JP Hughes Christopher J CJ Hahne Hannes H Ruprecht Benjamin B Pachl Fiona F Grzyb Arkadiusz A Richardson Keith K Wildgoose Jason J Maier Stefan K SK Marx Harald H Wilhelm Mathias M Becher Isabelle I Lemeer Simone S Bantscheff Marcus M Langridge James I JI Kuster Bernhard B
Molecular & cellular proteomics : MCP 20140808 12
One of the limiting factors in determining the sensitivity of tandem mass spectrometry using hybrid quadrupole orthogonal acceleration time-of-flight instruments is the duty cycle of the orthogonal ion injection system. As a consequence, only a fraction of the generated fragment ion beam is collected by the time-of-flight analyzer. Here we describe a method utilizing postfragmentation ion mobility spectrometry of peptide fragment ions in conjunction with mobility time synchronized orthogonal ion ...[more]