Ontology highlight
ABSTRACT:
SUBMITTER: Pan WJ
PROVIDER: S-EPMC4256621 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Pan Wei-Jian WJ Köck Kathleen K Rees William A WA Sullivan Barbara A BA Evangelista Christine M CM Yen Mark M Andrews Jane M JM Radford-Smith Graham L GL Prince Peter J PJ Reynhardt Kaz O KO Doherty David R DR Patel Sonal K SK Krill Christine D CD Zhou Kefei K Shen Jing J Smith Lynn E LE Gow Jason M JM Lee Jonathan J Treacy Anthony M AM Yu Zhigang Z Platt Virginia M VM Borie Dominic C DC
British journal of clinical pharmacology 20141201 6
<h4>Aims</h4>AMG 181 pharmacokinetics/pharmacodynamics (PK/PD), safety, tolerability and effects after single subcutaneous (s.c.) or intravenous (i.v.) administration were evaluated in a randomized, double-blind, placebo-controlled study.<h4>Methods</h4>Healthy male subjects (n= 68) received a single dose of AMG 181 or placebo at 0.7, 2.1, 7, 21, 70 mg s.c. (or i.v.), 210 mg s.c. (or i.v.), 420 mg i.v. or placebo. Four ulcerative colitis (UC) subjects (n= 4, male : female 2:2) received 210 mg AM ...[more]