Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC4256757 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Wang Hui H Zhang Zhongyang Z Rose Sherri S van der Laan Mark M
Genetics 20140924 4
We present a novel semiparametric method for quantitative trait loci (QTL) mapping in experimental crosses. Conventional genetic mapping methods typically assume parametric models with Gaussian errors and obtain parameter estimates through maximum-likelihood estimation. In contrast with univariate regression and interval-mapping methods, our model requires fewer assumptions and also accommodates various machine-learning algorithms. Estimation is performed with targeted maximum-likelihood learnin ...[more]