Unknown

Dataset Information

0

Influence of neurobehavioral incentive valence and magnitude on alcohol drinking behavior.


ABSTRACT: The monetary incentive delay (MID) task is a widely used probe for isolating neural circuitry in the human brain associated with incentive motivation. In the present functional magnetic resonance imaging (fMRI) study, 82 young adults, characterized along dimensions of impulsive sensation seeking, completed a MID task. fMRI and behavioral incentive functions were decomposed into incentive valence and magnitude parameters, which were used as predictors in linear regression to determine whether mesolimbic response is associated with problem drinking and recent alcohol use. Alcohol use was best explained by higher fMRI response to anticipation of losses and feedback on high gains in the thalamus. In contrast, problem drinking was best explained by reduced sensitivity to large incentive values in mesolimbic regions in the anticipation phase and increased sensitivity to small incentive values in the dorsal caudate nucleus in the feedback phase. Altered fMRI responses to monetary incentives in mesolimbic circuitry, particularly those alterations associated with problem drinking, may serve as potential early indicators of substance abuse trajectories.

SUBMITTER: Joseph JE 

PROVIDER: S-EPMC4257498 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Influence of neurobehavioral incentive valence and magnitude on alcohol drinking behavior.

Joseph Jane E JE   Zhu Xun X   Corbly Christine R CR   DeSantis Stacia S   Lee Dustin C DC   Baik Grace G   Kiser Seth S   Jiang Yang Y   Lynam Donald R DR   Kelly Thomas H TH  

NeuroImage 20140923


The monetary incentive delay (MID) task is a widely used probe for isolating neural circuitry in the human brain associated with incentive motivation. In the present functional magnetic resonance imaging (fMRI) study, 82 young adults, characterized along dimensions of impulsive sensation seeking, completed a MID task. fMRI and behavioral incentive functions were decomposed into incentive valence and magnitude parameters, which were used as predictors in linear regression to determine whether mes  ...[more]

Similar Datasets

| S-EPMC10635092 | biostudies-literature
| S-EPMC3717547 | biostudies-literature
| S-EPMC5434181 | biostudies-literature
| S-EPMC7722067 | biostudies-literature
| S-EPMC4450856 | biostudies-literature
| S-EPMC4174677 | biostudies-literature
| S-EPMC8252120 | biostudies-literature
| S-EPMC5783770 | biostudies-literature
| S-EPMC6936214 | biostudies-literature
| S-EPMC8575245 | biostudies-literature