Influence of neurobehavioral incentive valence and magnitude on alcohol drinking behavior.

ABSTRACT: The monetary incentive delay (MID) task is a widely used probe for isolating neural circuitry in the human brain associated with incentive motivation. In the present functional magnetic resonance imaging (fMRI) study, 82 young adults, characterized along dimensions of impulsive sensation seeking, completed a MID task. fMRI and behavioral incentive functions were decomposed into incentive valence and magnitude parameters, which were used as predictors in linear regression to determine whether mesolimbic response is associated with problem drinking and recent alcohol use. Alcohol use was best explained by higher fMRI response to anticipation of losses and feedback on high gains in the thalamus. In contrast, problem drinking was best explained by reduced sensitivity to large incentive values

SUBMITTER: Joseph JE 

PROVIDER: S-EPMC4257498 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature