Ontology highlight
ABSTRACT:
SUBMITTER: Ericson VR
PROVIDER: S-EPMC4257696 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
PloS one 20141205 12
Forming the proper number of synapses is crucial for normal neuronal development. We found that loss of function of the phosphoinositide phosphatase mtm-6 results in a reduction in the number of synaptic puncta. The reduction in synapses is partially the result of MTM-6 regulation of the secretion of the Wnt ligand EGL-20 from cells in the tail and partially the result of neuronal action. MTM-6 shows relative specificity for EGL-20 over the other Wnt ligands. We suggest that the ability of MTM-6 ...[more]