Ontology highlight
ABSTRACT:
SUBMITTER: Houede N
PROVIDER: S-EPMC4257751 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Houédé Nadine N Pulido Marina M Mourey Loic L Joly Florence F Ferrero Jean-Marc JM Bellera Carine C Priou Frank F Lalet Caroline C Laroche-Clary Audrey A Raffin Mireille Canal MC Ichas François F Puech Alain A Piazza Pierre Vincenzo PV
The oncologist 20141029 12
<h4>Background</h4>Preclinical studies demonstrated that non-nucleoside reverse transcriptase inhibitors used for the treatment of HIV could antagonize tumor development. This led us to assess the efficacy of efavirenz in patients with metastatic castration-resistant prostate cancer (mCRPC) in a multicenter phase II study.<h4>Methods</h4>We used a Simon two-stage design and a 3-month prostate-specific antigen (PSA) nonprogression rate of 40% as a primary objective. Patients received 600 mg efavi ...[more]