Dataset Information

Human cardiovascular disease IBC chip-wide association with weight loss and weight regain in the look AHEAD trial.

ABSTRACT: The present study identified genetic predictors of weight change during behavioral weight loss treatment.Participants were 3,899 overweight/obese individuals with type 2 diabetes from Look AHEAD, a randomized controlled trial to determine the effects of intensive lifestyle intervention (ILI), including weight loss and physical activity, relative to diabetes support and education, on cardiovascular outcomes. Analyses focused on associations of single nucleotide polymorphisms (SNPs) on the Illumina CARe iSelect (IBC) chip (minor allele frequency >5%; n = 31,959) with weight change at year 1 and year 4, and weight regain at year 4, among individuals who lost ? 3% at year 1.Two novel regions of significant chip-wide association with year-1 weight loss in ILI were identified (p < 2.96E-06). ABCB11 rs484066 was associated with 1.16 kg higher weight per minor allele at year 1, whereas TNFRSF11A, or RANK, rs17069904 was associated with 1.70 kg lower weight per allele at year 1.This study, the largest to date on genetic predictors of weight loss and regain, indicates that SNPs within ABCB11, related to bile salt transfer, and TNFRSF11A, implicated in adipose tissue physiology, predict the magnitude of weight loss during behavioral intervention. These results provide new insights into potential biological mechanisms and may ultimately inform weight loss treatment.

SUBMITTER: McCaffery JM

PROVIDER: S-EPMC4257841 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Human cardiovascular disease IBC chip-wide association with weight loss and weight regain in the look AHEAD trial.

McCaffery Jeanne M JM Papandonatos George D GD Huggins Gordon S GS Peter Inga I Erar Bahar B Kahn Steven E SE Knowler William C WC Lipkin Edward W EW Kitabchi Abbas E AE Wagenknecht Lynne E LE Wing Rena R RR

Human heredity 20130927 2-4

<h4>Background/aims</h4>The present study identified genetic predictors of weight change during behavioral weight loss treatment.<h4>Methods</h4>Participants were 3,899 overweight/obese individuals with type 2 diabetes from Look AHEAD, a randomized controlled trial to determine the effects of intensive lifestyle intervention (ILI), including weight loss and physical activity, relative to diabetes support and education, on cardiovascular outcomes. Analyses focused on associations of single nucleo ...[more]

PMID: 24081232

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Project description:Obesity is a major global health problem and predisposes individuals to several comorbidities that can affect life expectancy. Interventions based on lifestyle modification (for example, improved diet and exercise) are integral components in the management of obesity. However, although weight loss can be achieved through dietary restriction and/or increased physical activity, over the long term many individuals regain weight. The aim of this article is to review the research into the processes and mechanisms that underpin weight regain after weight loss and comment on future strategies to address them. Maintenance of body weight is regulated by the interaction of a number of processes, encompassing homoeostatic, environmental and behavioural factors. In homoeostatic regulation, the hypothalamus has a central role in integrating signals regarding food intake, energy balance and body weight, while an 'obesogenic' environment and behavioural patterns exert effects on the amount and type of food intake and physical activity. The roles of other environmental factors are also now being considered, including sleep debt and iatrogenic effects of medications, many of which warrant further investigation. Unfortunately, physiological adaptations to weight loss favour weight regain. These changes include perturbations in the levels of circulating appetite-related hormones and energy homoeostasis, in addition to alterations in nutrient metabolism and subjective appetite. To maintain weight loss, individuals must adhere to behaviours that counteract physiological adaptations and other factors favouring weight regain. It is difficult to overcome physiology with behaviour. Weight loss medications and surgery change the physiology of body weight regulation and are the best chance for long-term success. An increased understanding of the physiology of weight loss and regain will underpin the development of future strategies to support overweight and obese individuals in their efforts to achieve and maintain weight loss.

Dataset Information

Human cardiovascular disease IBC chip-wide association with weight loss and weight regain in the look AHEAD trial.

Publications

Human cardiovascular disease IBC chip-wide association with weight loss and weight regain in the look AHEAD trial.

Similar Datasets

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