No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk.
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ABSTRACT:
SUBMITTER: Du M
PROVIDER: S-EPMC4257872 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk.
Du Mengmeng M Zhang Xuehong X Hoffmeister Michael M Schoen Robert E RE Baron John A JA Berndt Sonja I SI Brenner Hermann H Carlson Christopher S CS Casey Graham G Chan Andrew T AT Curtis Keith R KR Duggan David D Gauderman W James WJ Giovannucci Edward L EL Gong Jian J Harrison Tabitha A TA Hayes Richard B RB Henderson Brian E BE Hopper John L JL Hsu Li L Hudson Thomas J TJ Hutter Carolyn M CM Jenkins Mark A MA Jiao Shuo S Kocarnik Jonathan M JM Kolonel Laurence N LN Le Marchand Loic L Lin Yi Y Newcomb Polly A PA Rudolph Anja A Seminara Daniela D Thornquist Mark D MD Ulrich Cornelia M CM White Emily E Wu Kana K Zanke Brent W BW Campbell Peter T PT Slattery Martha L ML Peters Ulrike U Chang-Claude Jenny J Potter John D JD
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20140905 12
<h4>Background</h4>Calcium intake may reduce risk of colorectal cancer, but the mechanisms remain unclear. Studies of interaction between calcium intake and SNPs in calcium-related pathways have yielded inconsistent results.<h4>Methods</h4>To identify gene-calcium interactions, we tested interactions between approximately 2.7 million SNPs across the genome with self-reported calcium intake (from dietary or supplemental sources) in 9,006 colorectal cancer cases and 9,503 controls of European ance ...[more]
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