Ontology highlight
ABSTRACT:
SUBMITTER: Evangelou M
PROVIDER: S-EPMC4258092 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Evangelou Marina M Smyth Deborah J DJ Fortune Mary D MD Burren Oliver S OS Walker Neil M NM Guo Hui H Onengut-Gumuscu Suna S Chen Wei-Min WM Concannon Patrick P Rich Stephen S SS Todd John A JA Wallace Chris C
Genetic epidemiology 20141104 8
Pathway analysis can complement point-wise single nucleotide polymorphism (SNP) analysis in exploring genomewide association study (GWAS) data to identify specific disease-associated genes that can be candidate causal genes. We propose a straightforward methodology that can be used for conducting a gene-based pathway analysis using summary GWAS statistics in combination with widely available reference genotype data. We used this method to perform a gene-based pathway analysis of a type 1 diabete ...[more]