Ontology highlight
ABSTRACT:
SUBMITTER: Bharadwaj R
PROVIDER: S-EPMC4258154 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Neuron 20141113 5
Three-dimensional chromosomal conformations regulate transcription by moving enhancers and regulatory elements into spatial proximity with target genes. Here we describe activity-regulated long-range loopings bypassing up to 0.5 Mb of linear genome to modulate NMDA glutamate receptor GRIN2B expression in human and mouse prefrontal cortex. Distal intronic and 3' intergenic loop formations competed with repressor elements to access promoter-proximal sequences, and facilitated expression via a "car ...[more]