Ontology highlight
ABSTRACT:
SUBMITTER: Panka DJ
PROVIDER: S-EPMC4258469 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Panka David J DJ Buchbinder Elizabeth E Giobbie-Hurder Anita A Schalck Aislyn P AP Montaser-Kouhsari Laleh L Sepehr Alireza A Lawrence Donald P DP McDermott David F DF Cohen Rachel R Carlson Alexander A Wargo Jennifer A JA Merritt Ryan R Seery Virginia J VJ Hodi F Stephen FS Gunturi Anasuya A Fredrick Dennie D Atkins Michael B MB Iafrate A John AJ Flaherty Keith T KT Mier James W JW Sullivan Ryan J RJ
Molecular cancer therapeutics 20141015 12
BRAF inhibitors (BRAFi) have led to clinical benefit in patients with melanoma. The development of a blood-based assay to detect and quantify BRAF levels in these patients has diagnostic, prognostic, and predictive capabilities that could guide treatment decisions. Blood BRAF(V600E) detection and quantification were performed on samples from 128 patients with stage II (19), III (67), and IV (42) melanoma. Tissue BRAF analysis was performed in all patients with stage IV disease and in selected pa ...[more]