Ontology highlight
ABSTRACT:
SUBMITTER: Behari J
PROVIDER: S-EPMC4258504 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Behari Jaideep J Li Huanan H Liu Shiguang S Stefanovic-Racic Maja M Alonso Laura L O'Donnell Christopher P CP Shiva Sruti S Singamsetty Srikanth S Watanabe Yoshio Y Singh Vijay P VP Liu Qing Q
The American journal of pathology 20141007 12
β-catenin regulates the establishment of hepatic metabolic zonation. To elucidate the functional significance of liver metabolic zonation in the chronically overfed state in vivo, we fed a high-fat diet (HFD) to hepatocyte-specific β-catenin transgenic (TG) and knockout (KO) mice. Chow-fed TG and KO mice had normal liver histologic findings and body weight. However, HFD-fed TG mice developed prominent perivenous steatosis with periportal sparing. In contrast, HFD-fed KO mice had increased lobula ...[more]