Ontology highlight
ABSTRACT:
SUBMITTER: Duan B
PROVIDER: S-EPMC4258511 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Cell 20141120 6
Pain information processing in the spinal cord has been postulated to rely on nociceptive transmission (T) neurons receiving inputs from nociceptors and Aβ mechanoreceptors, with Aβ inputs gated through feed-forward activation of spinal inhibitory neurons (INs). Here, we used intersectional genetic manipulations to identify these critical components of pain transduction. Marking and ablating six populations of spinal excitatory and inhibitory neurons, coupled with behavioral and electrophysiolog ...[more]