Ontology highlight
ABSTRACT:
SUBMITTER: Lobov IB
PROVIDER: S-EPMC4259146 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Nature 20050901 7057
Macrophages have a critical role in inflammatory and immune responses through their ability to recognize and engulf apoptotic cells. Here we show that macrophages initiate a cell-death programme in target cells by activating the canonical WNT pathway. We show in mice that macrophage WNT7b is a short-range paracrine signal required for WNT-pathway responses and programmed cell death in the vascular endothelial cells of the temporary hyaloid vessels of the developing eye. These findings indicate t ...[more]