Ontology highlight
ABSTRACT:
SUBMITTER: Xu X
PROVIDER: S-EPMC4259271 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Xu Xiangbin X Ha Chang-Hoon CH Wong Chelsea C Wang Weiye W Hausser Angelika A Pfizenmaier Klaus K Olson Eric N EN McKinsey Timothy A TA Jin Zheng-Gen ZG
Arteriosclerosis, thrombosis, and vascular biology 20070906 11
<h4>Background</h4>Angiotensin II (Ang II) induces the phenotypic modulation and hypertrophy of vascular smooth muscle cells (VSMCs), which is implicated in the pathogenesis of hypertension, atherosclerosis, and diabetes. In this study, we tested the hypothesis that histone deacetylases 5 (HDAC5) and its signal pathway play a role in Ang II-induced VSMC hypertrophy.<h4>Methods and results</h4>VSMCs were isolated from the thoracic aortas of male Sprague-Dawley rats and treated with Ang II. We fou ...[more]