Ontology highlight
ABSTRACT:
SUBMITTER: Jacobson JD
PROVIDER: S-EPMC4259400 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Jacobson Jill D JD Ellerbeck Kathryn A KA Kelly Kelsie A KA Fleming Kandace K KK Jamison T Rene TR Coffey Charles W CW Smith Catherine M CM Reese R Matthew RM Sands Scott A SA
Psychoneuroendocrinology 20131126
The neurotransmitter oxytocin plays an important role in social affiliation. Low oxytocin levels and defects in the oxytocin receptor have been reported in childhood autism. However, little is known about oxytocin's post-receptor signaling pathways in autism. Oxytocin signals via stimulatory and inhibitory G proteins. c-fos mRNA expression has been used as a marker of OT signaling as well as of G protein signaling. Herein, we hypothesized that oxytocin and its signaling pathways would be altered ...[more]